HYALOVISC 1%-PFS Gel

Ingredient

• Sodium hyaluronate 20 mg in 2 ml (1%),
• MW two million Da, 

Indication

• Rheumatoid arthritis, osteoarthritis,

Administration & Dosage

• Injection area should be clean and free of any microorganism and skin diseases,

• Intra-articular injection with disposable syringe,

Pharmaceutical Form

• PFS gel,

Advantage

• Clinical Trials have shown that injections into the knee reduce the symptoms of the disease for at least 6 months to 1 year,

Drug Interactions

• Without any interactions,

Adverse Drug Reactions

• Topical pain at the time of injection, swelling and stiffness that may last from 2-7 days,
• This complication was probably due to local injection which is reversible and doesn’t prevent the use of HA injection,

Mechanism of Action

• The high MW HA replace the synovial fluid and improves joint function,
• The HA injection stimulates the body to make more hyaluronic acid,
• Hyaluronic acid stabilizes the collagen network and protect the Articular cartilage against abrasion and prevents the stimulation of pain receptors,

Contraindications & Precautions

• Allergic Reaction,
• The bleeding disorders such as Hemophilia and anticoagulant users,
• Pregnant or nursing mother,
• Cancer patients,

Storage

• Store in a dry place, keep away from direct sunlight and 20-25 ^°C.